Integrate Multi-omics Analysis
Untargeted metabolomics
Map LC-MS/MS features to pathways using adduct-aware annotation, molecular networking, in silico ID, and evidence weighting.
Cross-reference with RNA-Seq
Overlay differential expression on the same pathways to pinpoint concordant metabolic-transcriptional signals.
e.g. upregulated enzymes with matching product/precursor shifts
Microbe-host integration
Explain why subgroups differ and tailor dosing or inclusion criteria.
Lead prioritization
Pick targets/transporters with multi-omic support for follow-up.
Decision Outputs
Rank drug-gable nodes, transporters, and enzymes: nominate biomarkers: stratify responders vs. non-responders.
Microbe-metabolite network (adapted from Alexey V. Melnik et al., Analytical Chemistry)
Typical Use Cases
Mechanism of action
Connect an intervention to pathway changes across metabolome, transcriptome and microbiome.
Biomarker Discovery
Identify pathway-anchored panels for efficacy or safety readouts.
Responder Stratification
Explain why subgroups differ and tailor dosing or inclusion criteria.
Lead prioritization
Pick targets/transporters with multi-omic support for follow-up.
Claims support
Pathway-level evidence packages for R&D, regulatory, or marketing.
Deliverables
• Ranked pathway and target lists with effect sizes and confidence
• Publication/regulatory-ready methods + figures; reproducible notebooks/pipelines