Our Mission

Clarity Genomics uses advanced algorithms to analyze host-microbiome data and provide valuable interpretations for clinical research. We work closely with clients to offer biological insights that empower accelerated development of microbiome-based therapeutics and diagnostics.  Partnerships with leading research institutions ensure that your project receives relevant information utilizing technologies and techniques on the forefront of innovation.

Secure Cloud Data Analysis

Clarity Genomics leverages secure cloud computing (including security and privacy compliance in accordance with HIPPA, and reproducibility and documentation for CLIA compliance, for high-throughput data) and integrates world-class bioinformatic analysis methods and databases, such as the American Gut Project, the Earth Microbiome Project and the NIH Human Microbiome Project to provide interpretation for host-microbiome clinical data.

Amplicon Sequencing

Who is there?

Sequencing of ribosomal RNA and ITS region is widely used for taxonomic classification and abundance estimation of bacteria, archaea and small eukaryotes in complex microbial communities.

Shotgun Metagenomics

What can they do?

Sequencing of all DNA in a sample allows for genome-wide taxonomic classification and function profiling of all microorganisms in a sample, including bacteria, archaea, eukaryotes, protozoa and viruses.

Shotgun Metatranscriptomics

What are they doing?

Sequencing of all RNA in a sample allows for gene expression abundance estimation and differential gene expression analysis, as well as taxonomic classification (if total RNA is available).

Metabolomics

How do the host and microbiome communicate?

Non-targeted metabolite profiling can be used for identification and quantification of host and microbial-derived small molecules such as short chain fatty acids, organic acids, vitamins and lipids. Analysis of host-microbiome exchange of metabolite information can help to explain microbial modulation of host immune response.

Genotyping

Do host genetic variations influence the microbiome?

Single nucleotide polymorphisms (SNPs) measure genetic variation between individuals and can be identified using genotyping chips, whole-genome sequencing or host DNA from shotgun metagenomic data (given sufficient depth). Identifying microbiome correlated host genes can elucidate effects of host genetic variation on microbiome structure & function.

Microbiome-Host Connection

The goal of human microbiome research is to understand how human microbiota communicate with their host and factors that influence these interactions in health and disease. An imbalance in human microbiome structure or metabolic activity has been observed in many diseases including inflammatory bowel disease, irritable bowel syndrome, type 2 diabetes, obesity, and cancer. Moreover, host genetic variation can influence microbiome composition and provide valuable information on therapeutics response. Integrative analysis of multiple data types (proteins, genes, metabolites, biomarkers, clinical metadata, etc.) can provide high-resolution understanding of mechanisms governing host-microbiome interactions under different conditions.

Clarity Genomics in the News

Johnson & Johnson Innovation Announces New Collaborations Advancing Ground-Breaking Biomedical Innovation Around the Globe

NEW BRUNSWICK, N.J., June 15, 2017 /PRNewswire/ -- Johnson & Johnson Innovation LLC today announced new collaborations that seek to develop potential treatments for diseases in urgent need of solutions, including obesity and related complications, such as type 2 diabetes and non-alcoholic steatohepatitis (NASH), and rheumatoid arthritis, and advance cutting-edge technologies, including 3-D printing to create customized health solutions.